Treatment of amyotrophic lateral sclerosis

Details Treatment of amyotrophic lateral sclerosis Treatment of amyotrophic lateral sclerosis

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 9/00 (2006.01) A61P 25/14 (2006.01)

Patent

CA 2568158

The present invention relates to the treatment of motoneuron diseases. More particularly the invention relates to the treatment of amyotrophic lateral sclerosis (ALS). It is found that the intracerebroventricular delivery of low amounts of vascular endothelial growth factor into a preclinical ALS animal model induces a significant motor performance and prolongation of survival time of said animals.

L'invention concerne un traitement de maladies des motoneurones. En particulier, l'invention concerne le traitement de la sclérose latérale amyotrophique (SLA). Dans l'invention, on a découvert que l'administration intracérébroventriculaire de faibles quantités d'un facteur de croissance endothéliale vasculaire dans un modèle animal SLA préclinique induit une performance moteur et une prolongation significatives de la durée de vie des animaux ayant subi ce traitement.

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