Indoloquinone tumor radiation sensitization

Details Indoloquinone tumor radiation sensitization Indoloquinone tumor radiation sensitization

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2600386

This invention generally relates to Indoloquinone caused tumor radiation therapy sensitization. More specifically, this invention relates to the discovery of indoloquinones as a radiation sensitizer (radiation therapy adjuvant) due to its ability to selectively target hypoxic cells and to damage the DNA of these hypoxic cells. Indoloquinones do so with minimal normal cell and tissue toxicity.

D'une manière générale la présente invention a trait à la sensibilisation à la radiothérapie des tumeurs par l'indoloquinone. De manière plus spécifique, l'invention a trait à la découverte d'indoloquinones en tant qu'agents de sensibilisation à la radiothérapie (adjuvant de radiothérapie) grâce à sa capacité de ciblage sélectif de cellules hypoxiques et à l'endommagement de l'ADN de ces cellules hypoxiques. Les indoloquinones réalisent cet effet avec une toxicité minimale des cellules et tissus normaux.

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