C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2584812
The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to express both cytochrome P-450 and the fdxshe or fdxshe-like protein. The invention further relates to the use of such microorganisms in processes designed for production of pravastatin for use in treatment of disease such as hypercholesterolemia and hyperlipidemia.
L'invention concerne des procédés et des compositions de production de pravastatine à partir de microbes. Ces compositions contiennent de nouvelles souches de micro-organismes capables d'hydroxyler efficacement la compactine (ML-236 B), ce qui permet de produire de la pravastatine. Les micro-organismes selon l'invention sont génétiquement modifiés afin d'exprimer à la fois le cytochrome P-450 et la protéine fdxshe ou de type fdxshe. L'invention concerne également l'utilisation de ces micro-organismes dans des processus de production de pravastatine destinée à être utilisée dans le traitement de maladies telles que l'hypercholestérolémie ou l'hyperlipidémie.
Szabo Lorand
Tchelet Ronen
Heenan Blaikie Llp
Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag
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