Pharmaceutical composition for the treatment of certain...

A - Human Necessities – 61 – K

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A61K 38/06 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2159116

A new pharmaceutical composition and the procedure of its preparation are disclosed, useful in the treatment of AIDS of certain viruses and autoimmune diseases and formulated as an aqueous injectable, or orally administered solution. Four examples are given of the pharmaceutical composition according to the invention. Example I: the pharmaceutical composition is composed of the calcium and sodium double salt of ethylenediaminetetraacetic acid, associated with calcium gluconate, reduced glutathione and sodium metabisulfite, wherein the weight ratio of the ingredients ranges from 5-10.5 g to 0.2-2 g to 0.01-0.1 g to 0.01-0.2 g respectively per 100 ml of water. Example II: the calcium disodium salt of ethylenediaminetetraacetic acid associated with calcium gluconate and L-histidine wherein the weight ratio for the active ingredients ranges from 5-10.5 g to 0.3-1 g to 0.05-0.2 g respectively per 100 ml of water. Example III: the calcium and sodium salt of diethylenetriaminepentaacetic acid (DTPA Na3Ca) associated with calcium gluconate, L-cysteine hydrochloride and sodium metabisulfite, the association weight ratio of the ingredients is 5-10 g to 0.4-1 g to 0.03-0.15 g to 0.05-0.15 g respectively per 100 ml water. Example IV: the calcium disodium salt of ethylenediaminetetraacetic acid associated with calcium gluconate, L-cysteine hydrochloride and sodium metabisulfite, wherein the weight ratio of the four active ingredients ranges from 9-11 g to 0.4-0.8 g to 0.1-0.3 g to 0.1-0.3 g respectively per 100 ml of water.

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