C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 9/22 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2275434
The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as well as to the isolated voltage-sensitive sodium channels of Musca domestica encoded thereby. Nucleic acid molecules encoding insecticide susceptible VSSCs and nucleic acid molecules encoding insecticide resistant VSSCs are provided. Methods for increasing or decreasing the expression of functional voltage-sensitive sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage-sensitive sodium channels.
L'invention concerne des molécules d'acide nucléique isolées codant pour un canal sodique sensible à la tension (VSSC) de musca domestica, ledit VSSC étant capable de conférer une sensibilité aux insecticides ou une résistance aux insecticides à musca domestica, ainsi que des canaux sodiques isolés sensibles à la tension de musca domestica codés par celles-ci. Les molécules d'acide nucléique codant pour les VSSC sensibles aux insecticides et les molécules d'acide nucléique codant pour des VSSC résistantes aux insecticides sont décrites. L'invention porte, en outre, sur des procédés pour augmenter ou réduire l'expression de canaux sodiques fonctionnels sensibles à la tension, sur des procédés dans lesquels lesdits canaux sodiques sont utilisés et sur un procédé d'isolement d'autres canaux sodiques sensibles à la tension.
Ingles Patricia J.
Knipple Douglas C.
Soderlund David M.
Cornell Research Foundation Inc.
Gowling Lafleur Henderson Llp
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