Mutants of streptococcal toxin a and methods of use

Details Mutants of streptococcal toxin a and methods of use Mutants of streptococcal toxin a and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2273822

This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.

L'invention concerne des toxines de mutants de streptocoques du groupe A ou des fragments de celles-ci, des compositions vaccinales et pharmaceutiques, ainsi que des procédés d'utilisation de celles-ci. La toxine streptococcique A préférée présente au moins un changement d'acide aminé et elle est sensiblement non mortelle par rapport à la toxine streptococcique A de type sauvage. Les toxines streptococciques A mutantes peuvent former des compositions vaccinales utiles pour protéger des animaux contre les activités biologiques de la toxine streptococcique A de type sauvage.

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