Tissue protective tocopherol analogs

Details Tissue protective tocopherol analogs Tissue protective tocopherol analogs

C - Chemistry, Metallurgy

07

D

C07D 311/72 (2006.01) A61K 31/355 (2006.01) A61K 31/38 (2006.01) C07D 311/58 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2084961

This invention relates to 2H-1-benzopyrans of the formula: Image wherein Q is S~R1R2.cndot.X~, x is a halide or OS(O)2R3, with R3 being H, C1-6 alkyl, CF3, aryl or aralkyl, R1 is C1-6 alkyl, phenyl, benzyl or phenethyl, R2 is C1-6 alkyl, and R1 and R2 are a C4- to C6 al- kylene which, together with the sulfur atom to which they are attached, form a 5-, 6- or 7- membered ring, R5 is H or C1-6 alkyl, R6 is H or -C(O)R, R being H or C1-9 alkyl, R7 is H or C1-6 alkyl, and R8 is H or C1-6 alkyl and n is an integer of 1 to 6, to the intermediates and processes useful for their preparation, to their free-radical scavenger and car- dioprotective properties and to their end-use applica- tion as therapeutic agents.

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