A method of treating insomnia

Details A method of treating insomnia A method of treating insomnia

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 9/52 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2746884

A method of treating insomnia comprising administering to a subject a formulation including zaleplon, wherein the formulation is adapted to release the zaleplon after a lag time of at least about one hour after administration of the formulation, and during which substantially no drug substance is released; provide a time of peak plasma concentration of about 3 hours to about 6 hours after administration; provide an elimination half-life after the time of peak plasma concentration of about 0.5 hours to about 0.3 hours; and provide an area under the curve of about 70 ng.cndot.h/mL to about 90 ng.cndot.h/mL.

L'invention concerne une méthode de traitement des insomnies comprenant l'administration à un sujet d'une formule incluant du zaleplon, la formule étant adaptée à la libération du zaleplon après un temps de latence d'au moins une heure après administration de la formule, pendant lequel substantiellement aucune substance médicamenteuse n'est libérée, et la formule permettant d'obtenir un temps de concentration plasmatique maximale compris entre environ 3 heures et environ 6 heures après administration. La méthode selon l'invention permet d'obtenir un temps de demi-vie d'élimination après la concentration plasmatique maximale compris entre environ 0,5 heure et environ 0,3 heure, ainsi qu'une aire sous la courbe comprise entre environ 70 ng.h/mL et environ 90 ng.h/mL.

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