Serine rich peptide linkers

Details Serine rich peptide linkers Serine rich peptide linkers

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 9/96 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2100671

Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contain at least 40 % serine residues and preferably have the formula (Ser, Ser, Ser, Ser, Gly)y where y is ~ 1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.

Divulgation de lieurs peptidiques riches en sérine pour lier au moins deux domaines de protéine afin de former une protéine de fusion. Les lieurs peptidiques contiennent au moins 40 % de résidus de sérine et, de préférence, ont la formule (Ser, Ser, Ser, Ser, Gly)y, dans laquelle y est 1. Les domaines fusionnés résultants sont biologiquement actifs ensemble ou individuellement, plus solubles dans les milieux physiologiques et plus résistants à la protéolyse.

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