Pyrazolo-pyrimidine derivatives as mglur2 antagonists

Details Pyrazolo-pyrimidine derivatives as mglur2 antagonists Pyrazolo-pyrimidine derivatives as mglur2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2597608

The present invention relates to pyrrazolo-pyrimidine derivatives of formula (I): wherein R1 to R4 and A are as defined in the specification, a process for the manufacture thereof, their use for treating or preventing metabotropic glutamate receptors mediated disorders, their use for the preparation of medicaments for treating such disorders and pharmaceutical compositions containing said derivatives.

La présente invention concerne des dérivés de pyrazolopyrimidine de formule (I) : dans laquelle R1 à R4 et A sont tels que définis dans la description. L~invention concerne également un procédé pour leur fabrication, leur utilisation pour le traitement ou la prévention de troubles induits par les récepteurs du glutamate métabotropique, leur utilisation pour la préparation de médicaments destinés à traiter de tels troubles et des compositions pharmaceutiques contenant lesdits dérivés.

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