Inducible focal adhesion kinase cell assay

Details Inducible focal adhesion kinase cell assay Inducible focal adhesion kinase cell assay

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2497434

The cell-based assay of the present invention exploits the biology of FAK in conjunction an inducible gene expression system to exogenously control FAK expression and FAK phosphorylation at the tyrosine residue at position 397 (Y397). The cell-based assay of the present invention is flexible and can measure FAK phosphorylation at Y397, total FAK phosphorylation, identify mutant FAK proteins and measure a combination of protein and phosphotyrosine.

L'invention concerne un dosage cellulaire qui exploite le biologie de FAK conjointement avec un système d'expression génique inductible afin de contrôler depuis l'extérieur l'expression de FAK et la phosphorylation de FAK du résidu de tyrosine au niveau de la position 397 (Y?397¿). Ce dosage de cellule kinase de l'invention est flexible et peut mesurer le phosphorylation de FAK au niveau de Y397, la phosphorylation de FAK totale, identifier les protéines de FAK mutantes et mesurer une combinaison de protéine et de phosphotyrosine.

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