New acyclic amidine group-containing diphosphonic acid...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 31/663 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2138127

Compounds of the formula I (See formula I) in which R1 signifies hydrogen, a straight-chained, branched, saturated or unsaturated alkyl radical with 1 - 9 carbon atoms possibly substituted by phenyl or a phenyl ring which is possibly substituted by C1-C3- alkyl, C1-C3-alkoxy or halogen, R2 signifier hydrogen or C1-C3-alkyl, whereby the two radicals can be the same or different, R represents hydrogen or a straight- chained or branched alkyl radical with 1-4 carbon atoms, X signifies an alkylene chain with 1-6 carbon atoms which can be substituted one or more times by C1-C3-alkyl and can possibly be interrupted by oxygen, whereby 1 or 2 carbon atoms of the alkylene chain can possibly be part of a cyclopentyl or cyclohexyl ring and Y signifies hydrogen, hydroxyl or amino group possibly substituted by alkyl groups with 1 - 6 carbon atoms, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medicaments for the treatment of calcium metabolism disturbances.

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