Thyroid receptor ligands

Details Thyroid receptor ligands Thyroid receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 25/24 (2006.01) C07D 249/12 (2006.01) C07D 271/07 (2006.01) C07D 277/20 (2006.01) C07D 403/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C11D 1/75 (2006.01) C11D 3/30 (2006.01)

Patent

CA 2344574

The invention provides thiazolidinedione, oxadiazolidinedione, and triazolone compounds of Formula (I): (see formula I) (in which X is a thiazolidinedione, oxadiazolidinedione or thiazolone ring bonded to the phenylene group optionally via CH2 or CH=; W is O, S, SO, SO2, CH2, CF2, CHF, CO, CH(OH) , NR a or C(=CH2) ; R1, R2, R3 and R6 are H, halo, etc.; R4 is H, alkyl, etc.; R5 is OH, O-alkyl, etc.; R a is H or alkyl) which are thyroid receptor ligands and are useful for treating obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer, diabetes, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesterolemia, depression, and osteoporosis.

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