Enzymatic synthesis of renin inhibitors

Details Enzymatic synthesis of renin inhibitors Enzymatic synthesis of renin inhibitors

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01)

Patent

CA 2075771

ENZYMATIC SYNTHESIS OF RENIN INHIBITORS ABSTRACT Peptipe renin inhibitors are synthesized by coupling component peptide acyl donors and nucleophiles in the presence of a class of proteases exhibiting certain minimum reaction velocities, regioselectivities and diastereoselectivities in a standardized enzymatic coupling reaction. An especially preferred subclass of proteases constitutes sulfhydryl proteases.

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