C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2359757
The invention provides novel LSR genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the LSR locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
L'invention concerne des séquences génomiques, des polypeptides, des anticorps et des polynucléotides LSR comprenant des marqueurs biallèles issus du locus LSR. L'invention concerne en outre des amorces capables d'hybridation avec les zones qui flanquent ces marqueurs. L'invention concerne également des polynucléotides et des procédés appropriés au génotypage d'un échantillon contenant un acide nucléique par rapport à un ou plusieurs marqueurs biallèles considérés. Enfin, l'invention concerne des procédés permettant de déceler une corrélation statistique entre un allèle de marqueur biallèle et un phénotype et/ou entre un haplotype de marqueur biallèle et un phénotype.
Bihain Bernard
Blumenfeld Marta
Bougueleret Lydie
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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