C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2291489
The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C1-C4 alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C9-C20 divalent hydrocarbon radical which can be saturated, straight or branched or Q stands for C4-C20 divalent hydrocarbon radical which can be cyclic or unsaturated and X stands for oxygen, sulfur or nitrogen the latter optionally being substituted by hydrogen or C1-C4 alkyl and R2 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, C1-C4 alkyl or alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulfamoyl or nitro; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.
L'invention concerne des composés jusque-là inconnus, de formule (I), leurs formes tautomères, leurs sels et leurs N-oxydes non toxiques pharmaceutiquement acceptables, dans lesquels le noyau pyridine se fixe en position 3 ou 4. Dans la formule (I), R¿1? représente un ou plusieurs substituants, identiques ou différents, choisis dans le groupe comprenant hydrogène, halogène, trifluorométhyle, carboxy, alkyle C¿1?-C¿4?, alcoxy, alcoxycarbonyle, nitro, amino ou cyano; Q représente un radical hydrocarboné divalent C¿9?-C¿20? pouvant être saturé, droit ou ramifié, ou bien Q représente un radical hydrocarboné divalent C¿4?-C¿20? pouvant être cyclique ou insaturé; X représente oxygène, soufre ou azote, ce dernier pouvant être substitué par hydrogène ou alkyle C¿1?-C¿4?; et R¿2? représente un ou plusieurs substituants, identiques ou différents, choisis dans le groupe comprenant hydrogène, alkyle C¿1?-C¿4?, alcoxy, hydroxy, halogène, trifluorométhyle, cyano, carboxamido, sulfamoyle ou nitro. Ces composés sont intéressants en pratique médicale et vétérinaire.
Borden Ladner Gervais Llp
Leo Pharmaceutical Products Ltd. A/s (lovens Kemiske Fabrik Prod
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