Monoclonal antibodies directed against eca and the use thereof

C - Chemistry – Metallurgy – 12 – P

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167/139, 167/37,

C12P 21/08 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) C12N 5/24 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2012079

ABSTRACT Monoclonal antibodies directed against ECA and the use thereof The present invention provides a process for the production or antibodies directed against Entero- bacteriaceae, wherein B-lymphocytes are obtained from the blood of donors in whom an Enterobacteriaceae infection has been detected, the lymphocytes are immortalised, the cells which produce antibodies with the desired activity are selected, cultured and the antibodies obtained therefrom. The present invention also provides medicaments containing antibodies produced by this process. The antibodies can be used for passive immunisation against infections brought about by Enterobacteriaceae and for the qualitative and quantitative detection of Entero- bacteriaceae.

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