C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/407 (2006.01) A61K 31/438 (2006.01) A61P 29/00 (2006.01) C07D 495/22 (2006.01)
Patent
CA 2604010
This invention is directed to spiroheterocyclic compounds of formula (I) : wherein (II) , k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
Cette invention concerne des composés spirohétérocycliques de formule (I) : dans laquelle k, j, p, Q, R1, R3a, R3b, R3c et R3d sont tels que définis dans le présent document, ainsi que leurs stéréoisomères, énantiomères, tautomères ou des mélanges de ceux-ci ; ou leurs sels, solvates ou promédicaments pharmaceutiquement acceptables, utiles pour le traitement et/ou la prévention de pathologies ou de troubles induits par le canal sodium. L'invention concerne également des compositions pharmaceutiques comprenant les composés et procédés d'utilisation de ces composés.
Bagherzadeh Mehran Seid
Chafeev Mikhail
Chowdhury Sultan
Fraser Robert
Fu Jianmin
Gowling Lafleur Henderson Llp
Xenon Pharmaceuticals Inc.
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