Treatment of skin wounds using polyenylphosphatidylcholine...

A - Human Necessities – 61 – K

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A61K 31/685 (2006.01) A61K 31/13 (2006.01) A61K 31/195 (2006.01) A61K 31/34 (2006.01) A61K 31/385 (2006.01) A61P 17/02 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2509232

Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minimize scar formation. Typical compositions contain from about 0.25% to about 12% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine, and from about 0.1% to about 10% by weight of an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine ehtylethanolamine, 2-butanolamine, choline, serine, or mixtures thereof. Dimethylaminoethanol is a particularly preferred alkanolamine. Tyrosine is an adjunct ingredient in many embodiments.

L'invention concerne de la polyénylphosphatidylcholine combinée à une alcanolamine, appliquées de manière topique, pour traiter des plaies cutanées, favoriser la cicatrisation, et réduire la formation de croûte. Des compostions typiques de l'invention contiennent de 0,25 % environ à 12 % environ d'une préparation de polyénylphosphatidylcholine provenant de sources naturelles, notamment de l'huile de soja contenant au moins 25 % en poids, de préférence environ 40 % ou plus de dilinoéoylphosphatidylcholine, et de 0,1 % environ à 10 % environ en poids d'une alcanolamine, notamment de l'éthylaminoéthanol, de méthylaminoéthanol, du diméthylaminoéthanol, de l'isopropanolamine, de la triéthanolamine, de l'isopropanoldiméthylamine, de l'éhtyléthanolamine, de la 2-butanolamine, de la choline, de la sérine, ou des mélanges de ceux-ci. Le diméthylaminoéthanol est une alcalonamine préférée. La tyrosine est un ingrédient associé dans plusieurs modes de réalisation de l'invention.

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