Attenuated vaccine for blastomyces dermatitidis

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/00 (2006.01) C07K 14/37 (2006.01) C12N 1/14 (2006.01)

Patent

CA 2342948

Disclosed herein are attenuated forms of the B. dermatitidis fungus. The fungus remains replication competent but is unable to express the WI-1 protein. One can administer this fungus to a dog, human, or other mammal to vaccinate them against the wild type fungus. Preferably, the administration is by subcutaneous injection.

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