A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01)
Patent
CA 2455856
The present invention relates to a method for targeting an agent towards a target site in a tissue comprising (a) administering to a tissue a multi- specific antibody (msAb) or multi-specific antibody fragment, comprising a targeting arm that binds to an antigen on the target site, and a capture arm that binds to a polymer conjugate; and (b) administering to the tissue a polymer conjugate that binds to the capture arm, with the polymer conjugate comprising a polymer conjugated to an agent selected from the group consisting of a therapeutic agent, a peptide, an enzyme and a labeled ligand. The present invention also relates to a kit, useful for targeting a target site in a tissue or tissue sample, comprising, (a) a multi-specific antibody or antibody fragment comprising a targeting arm that binds to an antigen on said target site, and a capture arm that binds to a polymer conjugate or hapten- polymer conjugate; and (b) a polymer conjugate that binds to the capture arm, with the polymer conjugate comprising a polymer conjugated to an agent selected from the group consisting of a therapeutic agent, a peptide, an enzyme and a labeled ligand.
L'invention concerne un procédé permettant de diriger un agent vers un site cible dans un tissu. Ce procédé consiste: à administrer un anticorps multi-spécifique ou un fragment d'anticorps comprenant un bras de ciblage et un bras de capture qui se fixe à un conjugué polymère; et à administrer un conjugué polymère au tissu. L'invention concerne également un kit permettant de cibler un site cible à l'intérieur d'un tissu qui contient un anticorps multi-spécifique ou un fragment d'anticorps comprenant un bras de ciblage et un bras de capture qui se fixe à un conjugué polymère, ainsi qu'un conjugué polymère.
Blake Cassels & Graydon Llp
Immunomedics Inc.
LandOfFree
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