Benzylamidine derivatives with serotonin receptor binding...

Details Benzylamidine derivatives with serotonin receptor binding... Benzylamidine derivatives with serotonin receptor binding...

C - Chemistry, Metallurgy

07

D

C07D 233/06 (2006.01) A61K 31/155 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07C 257/14 (2006.01) C07D 233/10 (2006.01) C07D 233/20 (2006.01) C07D 239/06 (2006.01) C07D 243/04 (2006.01)

Patent

CA 2246027

This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: (see above formula) wherein R1 is selected from a group of Formula i and ii: (see formula I and II) n is 1-3; R2 is selected from H and C1-6alkyl; R3 is selected from H and C1-6alkyl; R4 is selected from C1-6alkyl, halo, phenyl, amino and nitro; R5 is selected from H, C1-6alkyl and arylalkyl; R6 is selected from H or a alkylene group which is bonded to R4 to form the naphthalene ring skeleton; and salts, hydrates and solvates thereof. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.

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