System for benzodiazepine detection

Details System for benzodiazepine detection System for benzodiazepine detection

Category

G - Physics

Subcategory

01

Subsubcategory

N

IPC codes

G01N 33/94 (2006.01) C12S 3/24 (2006.01) G01N 30/46 (2006.01) G01N 30/88 (2006.01) G01N 33/483 (2006.01) G01N 30/02 (2006.01) G01N 30/06 (2006.01) G01N 30/08 (2006.01) G01N 30/14 (2006.01) G01N 30/34 (2006.01) G01N 30/74 (2006.01) G01N 30/86 (2006.01)

Type

Patent

Patent number

CA 2153904

Description

Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.

Système de détection à analyse isocratique unique des benzodiazépines utilisant une colonne chromatographique comportant un réacteur enzymatique immobilisé qui scinde les benzodiazépines à conjugaison d'acide glucuronique; une colonne échangeuse d'anions, une colonne échangeuse de cations et une colonne d'analyse en phase inversée. La méthode d'analyse préconisée prévoit en outre une précolonne d'échange hydrophobe de cations placée en amont de la colonne échangeuse d'anions. Le système qui se prête directement à l'automatisation, aux échantillonnages périodiques automatiques et à l'identification et à la quantification des benzodiazépines est particulièrement bien adapté à l'identification et à la quantification des benzodiazépines dans les urines.

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