Markers for detection of gastric cancer

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2532722

Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.

La détection précoce des tumeurs est un élément clé de la survie des patients atteints de tumeurs, et notamment de tumeurs de l'estomac. Les membres de la famille des gènes GTM peuvent être l'objet d'une surexpression dans le tissu tumoral de l'estomac, ainsi que dans d'autres tissus tumoraux. Cela fait qu'ils conviennent comme marqueurs pour le cancer de l'estomac ou d'autres types de cancers. Les protéines GTM peuvent être libérées par les cellules cancéreuses et atteindre des concentrations suffisamment élevées dans le sérum ou d'autres fluides pour en permettre la détection. Il en résulte que des procédés et des nécessaires de tests pour la détection et la quantification du GTM peuvent constituer un outil très intéressant pour le diagnostic du cancer de l'estomac.

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