Methods and compositions relating to ccr5 antagonist,...

Details Methods and compositions relating to ccr5 antagonist,... Methods and compositions relating to ccr5 antagonist,...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2548502

The present invention includes compositions and methods for the treatment of Thl and/or Th2 mediated inflammatory diseases, relating to inhibiting CCR5. This is because the present invention demonstrates, for the ferst time, that expression of IFN-7, IL~13, and CCR5, mediates and/or is associated with Thl and/or Th2 inflammatory diseases and that inhibiting CCR5 treats, and even prevents, the diseases. Thus, the Invention relates to the novel discovery that inhibiting CCR5 treats and prevents Thl and/or Th2 mediated inflammatory disease.

La présente invention se rapporte à des compositions et à des méthodes permettant le traitement de maladies inflammatoires médiées par Th1 et/ou Th2, en rapport avec l'inhibition du CCR5. Pour la première fois, la présente invention démontre que l'expression de IFN-.gamma., IL-13 et CCR5 favorise et/ou est associée aux maladies inflammatoires médiées par Th1 et/ou Th2 et que l'inhibition du CCR5 permet de traiter et même de prévenir ces maladies. Ainsi, l'invention se rapporte au fait que l'inhibition du CCR5 permet de traiter et de prévenir des maladies inflammatoires médiées par Th1 et/ou Th2.

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