A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/075 (2006.01) A61K 31/07 (2006.01) A61K 31/20 (2006.01) A61K 31/205 (2006.01) A61K 31/34 (2006.01) A61K 31/355 (2006.01)
Patent
CA 2432020
The present invention relates to a composition in liquid dosage form of coenzyme Q or ubiquinone which can be formulated into cosmetic, dietary supplement or pharmaceutical dosage form for administration to patients. The dosage form comprises an effective amount of coenzyme Q or ubiquinone ranging from about 0.05% to about 15%, more preferably about 1% to about 10.0% by weight of the composition in combination with a polysorbate surfactant such as a Tweentm surfactant, a vegetable oil or triglyceride, in further combination with a glyceryl ester in amounts effective to produce a liquid dosage form. Optional additives include a phospholipid such as hydroxylated lecithin, among others such as tocopherols or tocopherol esters effective to solubilize the ubiquinone in combination as well as other bioactive agents. Compositions according to the present invention avoid the inclusion of a polydydric alcohol solvent in solubilizing amounts.
L'invention concerne une composition sous forme posologique liquide de coenzyme Q ou d'ubiquinone pouvant être formulée sous forme posologique cosmétique, pharmaceutique ou de complément alimentaire à administrer à des patients. Ladite forme posologique comprend une quantité efficace de coenzyme Q ou d'ubiquinone comprise entre 0,05% et 15%, idéalement entre environ 1% et 10,0% en poids de la composition en combinaison avec un tensioactif de polysorbate tel qu'un tensioactif Tween?tm¿, une huile végétale ou un triglycéride, combinés ultérieurement avec un ester glycéryle en quantités efficaces pour produire une forme posologique liquide. D'éventuels additifs comprennent un phospholipide tel qu'une lécithine hydroxylée, des tocophérols ou des esters de tocophérol efficaces pour solubiliser l'ubiquinone en combinaison ainsi que d'autres agents bioactifs. Les compositions de l'invention évitent l'inclusion d'un solvant d'acide polyhydrique dans des quantités de solubilisation.
Cassan Maclean
Chopra Raj K.
LandOfFree
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