Use of t-cell immune response cdna 7 (tirc7) for modulation...

Details Use of t-cell immune response cdna 7 (tirc7) for modulation... Use of t-cell immune response cdna 7 (tirc7) for modulation...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2486924

A novel use of T-cell immune response cDNA 7 (TIRC7) in angiogenic and anti- angiogenic therapy is described. Provided are agents such as anti-TIRC7 antibodies and methods of treatment which through modulating the activity of TIRC7 can be used for enhancing or suppressing angiogenesis and/or neovascularization, an important feature in many pathological conditions including wound healing, solid tumors, developing metastases, ischemic heart diseases and diabetic retinopathy. Furthermore, diagnostic methods for the detection of such diseases using TIRC7 specific agents are provided.

L'invention concerne une nouvelle utilisation de l'ADNc 7 à réponse immunitaire des lymphocytes T (TIRC7) dans une thérapie angiogénique et anti-angiogénique. Elle porte sur des agents tels que des anticorps anti-TIRC7 et des méthodes de traitement qui peuvent être utilisés, à travers la modulation de l'activité de TIRC7, afin d'améliorer ou de supprimer l'angiogenèse et/ou la néovascularisation, une caractéristique majeure de nombreuses conditions pathologiques comprenant la cicatrisation, les tumeurs solides, le développement de métastases, les maladies coronariennes ischémiques et les rétinopathies diabétiques. L'invention concerne aussi des méthodes diagnostiques permettant de détecter de telles maladies au moyen d'agents spécifiques à TIRC7.

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