Pleuripotent stem cells generated from adipose...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/10 (2006.01) C12N 5/0775 (2010.01) C12N 5/0793 (2010.01) A61K 35/12 (2006.01)

Patent

CA 2400485

The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. The invention also includes an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers.

L'invention concerne le domaine de cellules souches multipotentes, produites à partir de cellules de stroma dérivées de tissus adipeux, ainsi que l'utilisation de ces cellules souches. L'invention concerne notamment des cellules de stroma isolées, dérivées de tissus adipeux, que l'on a induit à exprimer au moins une caractéristique phénotypique d'un progéniteur neuronal, astroglial, hématopoïétique, ou cellule hépatique. L'invention concerne également une cellule de stroma, isolée, dérivée d'un tissu adipeux, et qui a été dédifférenciée de façon qu'elle présente une absence de marqueurs phénotypiques des adipocytes.

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