C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2367468
As a disease gene for rheumatoid arthritis present in human chromosome X and a method of diagnosing rheumatoid arthritis, a disease gene, which is a mutant of protooncogene Dbl transcribing an mRNA that encodes the cDNA of which the sequence from the 2679th to 2952nd bases is shown in SEQ ID NO: 1, which disease gene transcribes an mRNA encoding the cDNA of which the region from the 20th to 274th bases in SEQ ID NO: 1 is substituted with the sequence of SEQ ID NO: 2, and a method for diagnosing rheumatoid arthritis by detecting the mRNA of the above-described gene or its expression product in a biological specimen, is provided.
Divulgation d'un gène de la polyarthrite rhumatoïde présent dans le chromosome X humain, qui est une séquence variante d'un gène proto-oncogène Dbl transcrivant un ARNm codant l'ADNc dont la séquences des bases des positions 2679 à 2952 est représentée par SEQ ID NO:1, caractérisé en ce qu'il y a transcription d'un ARNm codant un ADNc dans lequel la région des bases des positions 19 à 274 de SEQ ID NO:1 a été substituée par la séquence repésentée par SEQ ID NO:2. Divulgation aussi d'une méthode de diagnostic de la polyarthrite rhumatoïde par détection de l'occurrence de l'ARNm du gène susmentionné ou de son expression dans un échantillon biologique.
Komai Koichiro
Shiozawa Shunichi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Shiozawa Shunichi
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