Method of acylating maytansinol with chiral amino acids

Details Method of acylating maytansinol with chiral amino acids Method of acylating maytansinol with chiral amino acids

C - Chemistry, Metallurgy

07

D

C07D 491/00 (2006.01)

Patent

CA 2617953

This invention provides a method for making maytansinoids having a chiral amino acid side chain, such as DM1 and DM4 that are used to treat cancer. According to this method, the side chain may be added with little epimerization of the amino acid chiral center.

La présente invention concerne un procédé de production de maytansinoïdes présentant une chaîne latérale d'aminoacides chiraux, tels que DM1 et DM4 qui sont utilisés pour traiter le cancer. Selon ledit procédé, la chaîne latérale peut être ajoutée avec une faible épimérisation du centre chiral des aminoacides.

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