Atherosclerotic plaque specific antigens, antibodies...

Details Atherosclerotic plaque specific antigens, antibodies... Atherosclerotic plaque specific antigens, antibodies...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2060663

2060663 9102252 PCTABS00003 This invention provides purified antigens which are indicative of the presence of atherosclerotic plaque. Different concentrations of these antigens have been found to coincide with the progressiom of atherosclerosis. The subject invention also provides different hybridoma cell lines which produce monoclomal antibodies directed to antigens associated with atherosclerosis and a hybridoma cell line which produces monoclonal antibodies directed to antigen associated with normal artery and not with plaque. The atherosclerotic plaque antigen, and monoclonal antibodies made thereto, are used in various methods for detecting in a biological sample an antigen present in, and indicative of the presence of, atherosclerotic plaque.

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