Gene polymorphisms in vegf and vegf receptor 2 as markers...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2675305

The invention provides compositions and methods for determining the likelihood of successful treatment with anti-angiogenic antibodies or equivalent thereof, in combination with a pyrimidine based antimetabolite and a platinum-based alkylating agent based therapy. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.

L'invention propose des compositions et des procédés pour déterminer la probabilité de réussite d'un traitement avec des anticorps anti-angiogènes ou des équivalents de ceux-ci, en combinaison avec un antimétabolite à base de pyrimidine et une thérapie fondée sur un agent d'alkylation à base de platine. Les procédés comportent la détermination du polymorphisme génomique présent dans une région prédéterminée d'un gène d'intérêt et la corrélation du polymorphisme à la réponse prédictive. Des patients identifiés comme réactifs sont alors traités par la thérapie appropriée.

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