Inhibition of smooth muscle cell migration by (r)-amlodipine

Details Inhibition of smooth muscle cell migration by (r)-amlodipine Inhibition of smooth muscle cell migration by (r)-amlodipine

A - Human Necessities

61

K

A61K 31/44 (2006.01)

Patent

CA 2170278

The R(+) isomer of amlodipine is a potent inhibitor of smooth muscle cell migration despite its lack of calcium channel-blocking activity. It is useful for treating atherosclerosis, re-stenosis after angioplasty and endometriosis.

L'isomère R(+) de l'amlodipine est un puissant inhibiteur de la migration cellulaire de la fibre lisse malgré son manque d'activité de blocage de canal calcique. Cet isomère est utile dans le traitement de l'athérosclérose, de la récidive de sténose après une angioplastie ou une endométriose.

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