C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 31/00 (2006.01) A61K 31/095 (2006.01) C07K 14/18 (2006.01) C12N 7/00 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2186044
The present invention provides a composition of matter, comprising a non-infectious, mutated virus suitable for use in preparing a vaccine. A plasmid adapted for expression in a recombinant cell comprising DNA encoding non-infectious mutated virus protein and regulatory elements necessary for expression of said DNA in the cell. Also provided are methods of inhibiting the spread of infection of a virus comprising the step of contacting said virus with a compound that inhibits thiol-reductase/protein disulfide isomerase activity in said virus.
Cette invention concerne une composition de matière comprenant un virus muté non infectieux qu'on peut utiliser pour préparer un vaccin. On présente également un plasmide adapté pour l'expression dans une cellule de recombinaison comprenant de l'ADN qui code une protéine de virus muté non infectieux et des éléments de régulation nécessaires pour l'expression dudit ADN dans la cellule. Cette invention concerne également des procédés permettant d'inhiber la propagation de l'infection due à un virus qui comprennent une étape de mise en contact dudit virus avec un composé qui inhibe l'activité thiol-réductase/bisulfure isomérase de protéine dans ledit virus.
Borden Ladner Gervais Llp
Research Development Foundation
LandOfFree
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