A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) A61K 31/00 (2006.01) A61K 31/336 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2391277
A method of killing cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism. Alternatively, growth of tumor cells may be inhibited by FAS inhibition in conjunction with inhibition of carnitine palmitoyltransferase-1 (CPT-1). Combination therapy with drug(s) that inhibit fatty acid synthesis by inhibiting acetyl CoA carboxylase (the first enzyme in the fatty acid synthesis pathway) and drug(s) that inhibit CPT-1 e.g. etomoxir may be expected to induce apopptosis in tumor cells.
La présente invention concerne un procédé permettant d'éliminer des cellules cancéreuses, par augmentation aiguë de malonyl coenzyme A cellulaire (malonyl CoA), conduisant à l'apoptose. L'augmentation de malonyl CoA peut être induite par inhibition de la synthase d'acides gras (FAS), ou par d'autres manipulations du métabolisme des acides gras. En variante, la croissance des cellules tumorales peut être inhibée par inhibition de la FAS, en conjugaison avec l'inhibition de carnitine palmitoyltransférase-1 (CPT-1). La thérapie de combinaison avec un/des médicament(s) qui inhibe(nt) la synthèse d'acides gras, par inhibition de l'acétyle CoA carboxylase (la première enzyme dans la voie de synthèse des acides gras) et un/des médicament(s) qui inhibe(nt) la CPT-1, par exemple l'étomoxir, peut être susceptible d'induire l'apoptose dans des cellules tumorales.
Kuhajda Francis P.
Pizer Ellen S.
Townsend Craig A.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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