Epitopic regions of pneumococcal surface protein a

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/12 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) C07K 14/715 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2116261

34 ABSTRACT OF THE DISCLOSURE A region of the PspA protein of the Rx1 strain of Streptococus pneumoniae has been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S.pneumoniae strains. The region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA strain.

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