Oxidative method for attachment of glycoproteins to surfaces...

A - Human Necessities – 61 – L

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A61L 33/00 (2006.01) A61L 27/00 (2006.01) A61L 27/28 (2006.01) A61L 27/34 (2006.01) A61L 29/08 (2006.01) A61L 31/08 (2006.01) A61L 31/10 (2006.01) C07K 17/06 (2006.01) C08F 8/06 (2006.01) C08G 14/073 (2006.01)

Patent

CA 2212602

A method for making a medical device having a glycoprotein immobilized on a substrate surface is provided. The method includes oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; combining thealdehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and reacting the imine moiety with areducing agent to form a secondary amine.

Méthode de fabrication d'un instrument médical comprenant une glycoprotéine immobilisée sur une surface de substrat. Cette méthode vise à : oxyder 1,2 partie de dihydroxy avec un périodate, afin de former une matière fonctionnelle à l'aldéhyde; combiner cette matière fonctionnelle à l'aldéhyde avec une matière amino-fonctionnelle pour les lier ensemble avec une partie d'imine; faire réagir la partie d'imine avec un agent réducteur dans le but de former une amine secondaire.

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