A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61K 39/00 (2006.01) A61K 39/102 (2006.01) C07K 14/22 (2006.01)
Patent
CA 2489030
The present invention relates to immunogenic compositions and vaccines for the prevention or treatment of Gram negative bacterial infection. Immunogenic compositions of the invention comprise transferrin binding protein and Hsf, and the combination of these two antigens have been shown to act synergistically to produce antibodies with high activity in a serum bactericidal assay. This combination of antigens is useful for use in vaccines against Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis and Haemophilus influenzae.
L'invention concerne des compositions immunogènes et des vaccins destinés à la prévention et au traitement des infections bactériennes gram négatif. Ces compositions immunogènes comprennent des protéines de liaison à la transferrine et des Hsf, et il a été montré qu'en combinaison, ces deux antigènes agissent en synergie pour produire des anticorps présentant une activité élevée lors de la détermination du pouvoir bactéricide du sérum. Cette combinaison d'antigènes est utilisable dans des vaccins contre Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhaliset Haemophilus influenzae.
Berthet Francois-Xavier Jacques
Biemans Ralph
Denoel Philippe
Feron Christiane
Goraj Karine
Glaxosmithkline Biologicals S.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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