Methods of using and compositions comprising selective...

Details Methods of using and compositions comprising selective... Methods of using and compositions comprising selective...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A01N 43/42 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2565445

Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agent is capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of MPD. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Des procédés de traitement, de prévention et/ou de gestion d'une maladie myéloproliférative sont décrits. Des procédés spécifiques englobent l'administration d'un médicament d'inhibition sélective de la cytokine ou d'un sel, d'un solvate, d'un hydrate, d'un stéréo-isomère, d'un clathrate ou d'un précurseur de ceux-ci, acceptables en termes pharmaceutiques, seul ou en combinaison avec un second agent actif, et/ou la transplantation de sang ou de cellules. Un second agent actif particulier peut supprimer la surproduction de cellules souches hématopoïétiques ou améliorer un ou plusieurs des symptômes de la maladie myéloproliférative (MPD). Des compositions pharmaceutiques, des formes de dosage à élément unique et des trousses appropriées à une utilisation dans des procédés de l'invention sont également décrites.

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