Homogeneous preparations of chimeric proteins

Details Homogeneous preparations of chimeric proteins Homogeneous preparations of chimeric proteins

A - Human Necessities

61

K

A61K 38/16 (2006.01) A01N 43/04 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2546580

Variant forms of chimeric protein molecules comprising a Factor VII moiety and an Fe region of an IgG1 moiety provide improved properties. The variants are more resistant to proteolytic degradation. Thus preparations of the variant forms are more homogeneous and have a longer half-life. The variant forms are used for treating cancer, atherosclerosis, psoriasis, diabetic retinopathy, wet macular degeneration, and rheumatoid arthritis.

Cette invention concerne des formes variantes de protéines chimères comprenant une fraction de facteur VII et une région Fe de fraction IgG1 qui présentent des propriétés améliorées. Ces variants sont plus résistants à la dégradation protéolytique. Ainsi, ces préparations de formes variants sont plus homogènes et ont une demi-vie plus longue. Ces formes variantes sont utilisées dans le traitement du cancer, de l'athérosclérose, du psoriasis, de la rétinopathie diabétique, de la forme humide de la dégénérescence maculaire, et de la polyarthrite rhumatoïde.

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