Therapeutic human anti-mhc class ii antibodies and their uses

Details Therapeutic human anti-mhc class ii antibodies and their uses Therapeutic human anti-mhc class ii antibodies and their uses

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2538141

The instant invention relates to methods, compositions, uses related to the compositions and pharmaceutical packages for treating a disorder involving cells expressing MHC class II antigens using a combination of a human antibody- based antigen-binding domain that binds to a human Class II MHC molecule, and an antibody-based antigen-binding domain that binds to a cell surface receptor. Such disorders include cell proliferative disorders like lymphomas, leukemias, and certain solid tumors including melanomas, as well as disorders characterized by unwanted activation of immune cells like rheumatoid arthritis and multiple sclerosis.

L'invention concerne des méthodes, des compositions, les utilisations de ces compositions, ainsi que des emballages thérapeutiques, visant à traiter un trouble impliquant des cellules exprimant des antigènes MHC de classe II. Lesdites méthodes et compositions sont basées sur l'association d'un domaine de liaison à un antigène à base d'anticorps humain qui se fixe sur une molécule MHC humaine de classe II, et d'un domaine de liaison à un antigène à base d'anticorps qui se fixe sur un récepteur de surface cellulaire. Ces troubles comprennent les troubles de prolifération cellulaire, tels que les lymphomes, les leucémies et certaines tumeurs solides, notamment les mélanomes, ainsi que les troubles se caractérisant par une activation non désirée des cellules immunitaires, tels que la polyarthrite rhumatoïde et la sclérose en plaques.

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