C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) C07C 215/44 (2006.01) C07D 263/52 (2006.01) C07D 413/12 (2006.01) C12P 17/14 (2006.01) C12P 17/16 (2006.01)
Patent
CA 2061239
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H- cyclopent[d]oxazole-4,5,6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a- tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.
Ando Osamu
Enokita Ryuzo
Hamano Kiyoshi
Haruyama Hideyuki
Kinoshita Takeshi
Marks & Clerk
Sankyo Company Limited
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