Tricyclic benzazepine vasopressin antagonists

Details Tricyclic benzazepine vasopressin antagonists Tricyclic benzazepine vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2258885

Tricyclic compound of general Formula (I), as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

La présente invention concerne un composé tricyclique représenté par la formule générale (I). Ce composé, qui fait preuve d'une activité antagoniste au niveau des récepteurs V¿1? et/ou V¿2?, fait également preuve in vivo d'une activité antagoniste de la vasopressine. L'invention concerne également des thérapies utilisant de tels composés pour traiter des affections caractérisées par une réabsorption rénale excessive de l'eau. L'invention concerne enfin un procédé de préparation de tels composés.

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