Neural crest stem cells and uses thereof

Details Neural crest stem cells and uses thereof Neural crest stem cells and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/0735 (2010.01) C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61K 35/54 (2006.01)

Patent

CA 2528248

This present invention features methods and composition for the isolation and proliferation of neural crest stem cells (NCSCs) from embryonic tissues as well as from tissues from a post-natal mammal. According to this invention, NCSCs are capable of producing non-neuronal and neuronal cells under the appropriate conditions. The cells of the invention therefore provide an accessible source for autologous and heterologous transplantation into the central nervous system, the peripheral nervous system, as well as other damaged tissues.

La présente invention concerne des méthodes et une composition destinées à l'isolement et à la prolifération de cellules souches de la crête neurale (CSCN), à partir de tissus embryonnaires, ainsi que de tissus provenant d'un mammifère post-natal. Selon l'invention, les CSCN sont capables de produire des cellules non neurales ou neurales dans les conditions appropriées. Les cellules de l'invention constituent donc une source accessible pour la réalisation d'une transplantation autologue ou hétérologue dans le système nerveux central, le système nerveux périphérique, ou d'autres tissus endommagés.

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