Predictive toxicology for biological systems

Details Predictive toxicology for biological systems Predictive toxicology for biological systems

G - Physics

06

F

G06F 19/00 (2011.01)

Patent

CA 2528846

Methods and apparatus to identify a potential toxicity of a therapy in a biological system are described. In one embodiment, a method uses a computer model that represents a set of biological processes of the biological system. The method includes executing the computer model to identify a first set of biological processes contributing to the occurrence of a toxic state of the biological system. The method also includes identifying a set of biological assays based on the first set of biological processes and testing the therapy in the set of biological assays to identify a second set of biological processes modified by the therapy. The method further includes identifying the potential toxicity of the therapy based on the second set of biological processes.

L'invention concerne des méthodes et des dispositifs permettant d'identifier la toxicité potentielle d'une thérapie dans un système biologique. Dans un mode de réalisation, une des méthodes utilise un modèle informatique représentant un ensemble de processus biologiques du système biologique. Cette méthode consiste à exécuter le modèle informatique pour identifier un premier ensemble de processus biologiques induisant cet état toxique dans le système biologique. Cette méthode consiste également à identifier un ensemble d'analyses biologiques sur la base du premier ensemble de processus biologiques et à tester la thérapie dans l'ensemble d'analyses biologiques pour identifier un second ensemble de processus biologiques modifiés par la thérapie. La méthode consiste également à identifier la toxicité potentielle de la thérapie sur la base du second ensemble de processus biologiques.

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