C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/805 (2006.01) A01N 1/02 (2006.01) A61K 38/42 (2006.01) C07K 1/06 (2006.01) C07K 1/107 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2667332
The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, the hemoglobin is deoxygenated, endotoxin free, and stroma free. The present invention also includes method of preparation, process of preparation and the method of use including supplementing blood volume in mammals and treating disorders in mammals where oxygen delivery agents are of benefit.
La présente invention concerne des compositions qui contiennent de l'hémoglobine réticulée et carboxamidométhylée, la partie cystéine de l'hémoglobine contenant un groupe de protection thiol et l'hémoglobine ayant une capacité réduite à se lier à l'oxyde nitrique. L'hémoglobine est de préférence désoxygénée, exempte d'endotoxines et exemple de stromas. La présente invention concerne également un procédé de préparation, une opération de préparation et un procédé d'utilisation qui comprend l'augmentation du volume sanguin de mammifères et le traitement de maladies des mammifères lorsque des agents de fourniture d'oxygène sont bénéfiques.
Gowling Lafleur Henderson Llp
Ikor Inc.
LandOfFree
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