Alprazolam inclusion complexes and pharmaceutical...

A - Human Necessities – 61 – K

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A61K 47/40 (2006.01) A61K 31/5517 (2006.01) A61P 25/22 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2401424

Pharmaceutical composition for transmucosal delivery contains an inclusion complex of alprazolam and a water soluble unsubstituted or substituted beta- or gamma-cyclodextrin such as 2- hydroxypropyl beta-cyclodextrin, and a pharmaceutically acceptable carrier therefor. The pharmaceutical composition is of particular application in the treatment of Generalised Anxiety Disorder or for the management of panic disorders.

L'invention concerne une composition pharmaceutique destinée à l'administration transmucosale et qui contient un complexe d'inclusion d'alprazolame et de la beta- ou gamma - cyclodextrine substituée ou non, soluble dans l'eau, comme par exemple de la beta-cyclodextrine de 2-hydroxypropyle, et un transporteur acceptable au plan pharmaceutique prévu à cet effet. Cette composition pharmaceutique s'utilise particulièrement dans le traitement du trouble d'anxiété généralisé ou dans celui des troubles paniques.

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