Liposome bonded with antibody and polyalkylene glycol

Details Liposome bonded with antibody and polyalkylene glycol Liposome bonded with antibody and polyalkylene glycol

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2370043

A liposome constructed by bonding a compound having a polyalkylene glycol moiety to a liposome, which has been converted into maleimide in a part of lipid ends, via a thioether group and further bonding an antibody via the thioether group, wherein the ratio of the bonded compound and the bonded antibody are respectively from 15 to 50 % by mol and from 0.1 to 2 % by mol each per mol of the maleimide lipid contained in the liposome. This liposome is excellent both in the retentivity in the blood and therapeutic effect.

Cette invention se rapporte à un liposome construit par liaison d'un composé comportant une fraction polyalkylène-glycol à un liposome, lequel a été converti en maléimide dans une partie des extrémités d'un lipide, via un groupe thioéther, et par liaison ultérieure d'un anticorps via ce groupe thioéther. Le rapport entre le composé lié et l'anticorps lié est respectivement compris entre 15 et 50 % en mole et entre 0,1 et 2 % en mole, l'un et l'autre en pourcentage molaire du lipide de maléimide contenu dans le liposome. Ce liposome possède d'excellentes propriétés du point de vue de sa rétentivité dans le sang et de son effet thérapeutique.

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