A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 31/4045 (2006.01) A61K 31/422 (2006.01) A61K 31/48 (2006.01) A61P 25/06 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2454083
The present invention relates to a method of treatment or prevention of headache, migraine or cluster headaches, which method comprises co- administration of a therapeutically effective amount of the compound A = 1-[N2- [3,5-Dibromo-N-[[4-(3,4-dihydro-2(1 H)-oxochinazolin-3-yl)-1-piperidinyl]- carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096BS] or a physiologically acceptable salt thereof and a therapeutically effective amount of a second active antimigraine drug, particularly sumatriptan, zolmitriptan or dihydroergotamin or a physiologically acceptable salt thereof, as well as to the corresponding pharmaceutical compositions and the preparation thereof.
Méthode de traitement ou de prévention des céphalées, de la migraine ou de la céphalée vasculaire de Horton, qui consiste à administrer conjointement une quantité thérapeutiquement efficace du composé A = 1-[N?2¿-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1 H)-oxoquinazolin-3-yl)-1-pipéridinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-pipérazine [BIBN4096BS] ou d'un sel physiologiquement acceptable dudit composé et une quantité thérapeutiquement efficace d'un second médicament contre la migraine, en particulier le sumatriptan, le zolmitriptan ou la dihydroergotamine, ou d'un sel physiologiquement acceptable de ce second médicament. La présente invention concerne également les compositions pharmaceutiques correspondantes et leur préparation.
Doods Henri
Eberlein Wolfgang
Rudolf Klaus
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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