Inhibiting hiv infection by cleaving co-receptor rna

Details Inhibiting hiv infection by cleaving co-receptor rna Inhibiting hiv infection by cleaving co-receptor rna

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/38 (2006.01) A61K 45/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2269644

Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.

L'invention concerne des procédés d'inhibition de l'infection par le VIH consistant à bloquer l'expression de l'ARN co-récepteur du VIH. Elle porte également sur les ribozymes qui clivent l'ARN co-récepteur du VIH et qui inhibent l'infection des cellules par le VIH. Les cibles co-réceptrices comprennent la fusine et le CKR5.

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